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98 Park et al also found that the pro-apoptotic effect of apigenin on endometriosis cells and the inhibitory effect on cell proliferation were achieved through modulating MAPK and PI3K/Akt signaling pathways

Di Ciaula A, Garruti G, Fruhbeck G, De Angelis M, De Bari O, D QHW,

The main sources of ROS under physiological conditions include the mitochondrial respiratory chain, peroxisomes, NADPH oxidase (NOX), and lipoxygenase (ALOX), and additional ROS-producing enzymes, such as cyclooxygenases (COXs) and cytochrome p450s (CYPs) [12, 13]

Similarly, the increase observed in various metabolites participating in the phosphocreatine system (creatine, creatinine) and niacin metabolism (niacinamide, N1-methyl-4-pyridone-3-carboxamide), which are responsible for managing the energy pool (i.e., ATP, NADPH), further supports profound failures in catabolism