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Some reports demonstrated impaired regeneration whereas others could not confirm such effects [74, 75]

The oxycodone in ENDOCET may increase the frequency of seizures in patients with seizure disorders, and may increase the risk of seizures occurring in other clinical settings associated with seizures

Investigating the rational combinations of metabolic modulators (e.g., glycolysis + glutaminolysis inhibitors) or their integration with conventional DMARDs/biologics to achieve synergistic efficacy and overcome pathway redundancy