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third-line treatment includes renal replacement therapy, ascites concentrated transfusion and liver transplantation

doi: 10.1016/j.mam.2009.01.001 213 PaludanS

Mechanistically, we present the first direct evidence of a transcriptional negative regulatory relationship between Stat1 and Nrf2, with Crizotinib promoting this transcriptional activity, suggesting that inhibiting Stat1 could offer an intriguing intervention strategy