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It also causes cataracts to form faster than normal, resulting in decreased vision

These reports highlight the importance of including B12 deficiency in the differential diagnosis of TMA-like presentations to avoid unnecessary treatments and ensure timely, targeted therapy

A 2015 meta-analysis of 15 trials (1,106 patients) confirmed that IV methylcobalamin (5001,500 mcg/day) combined with alpha-lipoic acid improved nerve conduction velocity by 2030% more than monotherapy, reducing tingling and burning sensations

In the STEP 1 extension, participants who came off semaglutide regained roughly two thirds of the weight they had lost within a year, and the improvements in blood pressure, lipids and glycemic markers moved back toward baseline (PMID 35441470)