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( FIGURE 1 Growth hormone is mainly produced by the anterior pituitary gland, secreted in a pulsatile manner and under direct control of hypothalamic neuronal projections (Pombo et al., 2001), whose secretion is mainly regulated positively by growth hormone releasing hormone (GHRH), ghrelin (Khatib et al., 2014), and negatively by somatostatin (SS) (Lu et al., 2019)

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[DOI] [PubMed] [Google Scholar] 366.Jiang L, Cui X, Ma H, Tang X (2021) Comparison of denosumab and zoledronic acid for the treatment of solid tumors and multiple myeloma with bone metastasis: a systematic review and meta-analysis based on randomized controlled trials