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Comparative efficacy and safety of systemic therapies used in moderate-to-severe atopic dermatitis: a systematic literature review and network meta-analysis

They want to ensure they are bypassing the "absorption barrier" created by the digestive system

11 The plaques in symptomatic patients exhibited the characterization of a distinct CD4 + T-cell subset and T cells to be activated and differentiated, whereas in the plaques from asymptomatic patients, T cells and macrophages were also activated and raised interleukin-1 (IL-1) signaling