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However, the biological effectsincreased synaptic density, elevated expression of synaptogenic proteins like synaptophysin and PSD-95, and enhanced dendritic spine formationpersist for 7-14 days after administration

Two physicochemical factors contribute to P, namely the solubility of the drug in the membrane lipid and its diffusivity

Early impairment of NGF/TrkA signaling in AD can lead to reduced synaptic vesicle secretion and decreased presynaptic protein expression, resulting in presynaptic functional impairment of cholinergic primary neurons [88]