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However, in rare cases where central obesity is not present, liposuction may still be considered for individuals with a higher BMI.3,37,40 Although many studies reported improving the disease's symptoms, such as reduction of spontaneous pain, bruising, and mobility impairment, there is still not enough evidence to support liposuction as the gold standard in treating lipedema.37,54 It is also important to highlight that liposuction carries risks and potential complications, including post-procedural pain, infection, prolonged recovery, scarring, bruising, ecchymosis, edema, and substantial financial costs, which must be carefully considered in clinical decision-making.54 Bariatric surgery Bariatric surgery may be considered for individuals with lipedema and a BMI 40 kg/m2, and potentially for those with a BMI between 3540 kg/m2

The IPA software utilizes input data to infer and identify upstream regulators that, if altered, may explain the input data

Although applying it to the skin could help, the results might not show up immediately as they would with other approaches

Mandel S, Amit T, Reznichenko L, Weinreb O, Youdim MBH (2006) Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders