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As the tumor site is reached, the linker is selectively cleaved and the toxophore is released and thereby activated (Kratz et al., 2008)

This interaction is mediated by dual binding, with FHD mainly binding to the p53 TAD and FOXO4 CR3 binding to the p53 DNA-binding domain (DBD) 38 (Figure

When creating a new dosage form, they take care of customer needs, along with ingredient compatibility, rate of absorption, the avoidance of unpleasant odours or tastes, product stability and manufacturing efficiency

On the basis of these results, it could be deduced that a certain concentration of CaOx induces the occurrence of ferroptosis, and with the occurrence of ferroptosis, the damage inflicted on HK-2 cells gradually became severe, and the degree of damage increased in a concentration-dependent manner