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Losing excess weight and cutting down accumulated body fat is not only relevant for aesthetic body shape but being overweight and obese accounts for several cardiovascular and cardiometabolic disorders such as hypertension, coronary artery disease, diabetes mellitus, etc

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Areas such as deep abdominal fat (visceral adipose tissue) and lower body subcutaneous fat often demonstrate resistance to traditional fat loss approaches due to lower concentrations of beta-adrenergic receptors and higher concentrations of anti-lipolytic alpha-2 adrenergic receptors

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