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17 Compounding the issue is the fact that various professional organizations and grading references (the American Academy of Pediatrics, American Family Practice, Scottish Intercollegiate Guidelines Network, and many others) have different letter assignments and cutoffs for the use of non-RCT-containing literature, creating confusion about the meaning of an A, B, or C to denote the quality of literature used for evidence

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Proton pump inhibitors increase risk for hepatic encephalopathy in patients with cirrhosis in A population study