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Other acivicin-regulated genes are similarly affected by toxic metals (Cd 2+ and Hg 2+ ) (Fig

Key Areas of Preclinical Research Skin and Dermal Matrix Research GHK-Cu is widely studied in fibroblast cultures and skin models, where it has been associated with collagen and elastin synthesis, glycosaminoglycan production, and modulation of metalloproteinase activity

The glutathione redox state of the matrix is maintained separately from the IMS and the cytosol Our results also imply that the IMM prevents the equilibration of the glutathione pools in matrix and IMS in vivo and in vitro , and that the matrix has to rely on its own glutathione reduction machinery for maintaining E GSH

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