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For example, mitochondrial muscle diseases cause NAD + deficiency, detectable both in the muscle and blood 15,16

The role of GPxs in breast cancer As mentioned above, ROS is closely related to the molecular mechanism of breast cancer progression, and ROS can be directly regulated by GPxs, which eliminate organic peroxides at the expense of GSH [10]

Arabidopsis mutant phenotypes for cadmium tolerance ( cad2 ), plant disease resistance ( pad2 ), and post-embryonic root development ( rml1 ) are linked to the GCL gene (Cobbett et al., 1998