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Particularly in tumor cells with active glycolysis, accumulated lactate stabilizes and increases the activity of proglycolytic transcription factors such as HIF-1 and c-Myc, as well as the expression of their downstream target genes, via lactylation, thereby forming a self-reinforcing positive feedback loop that further entrenches the glycolytic phenotype of tumors [78, 79]

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In addition to adenosine receptor agonists and antagonists, drugs that target intracellular signaling moleculessuch as Ras proteins, G proteins, and the small GTPase Rhoare also being explored (94)

We placed both female and male 3xTg AD and NTg mice on different feeding regimens allowing us to distinguish between the effects of energy restriction and fasting