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Comment: One commenter opposed the proposal and recommended that for biosimilars with only negative or zero manufacturer's ASP data, CMS set the payment limit by calculating the volume-weighted ASP using the most recent positive manufacturer's ASP for each NDC in the billing and payment code, while using the current quarter's reported units sold for each NDC

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Metabolomic studies have displayed this altered cellular energetics, but the affected metabolites differ between studies (186, 269, 405407)

Bacteriostatic Water for Injection is a sterile, non-pyrogenic solution of water containing 0.9% benzyl alcohol as a preservative