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Acute symptoms such as fatigue may improve within days, whilst neurological symptoms like paraesthesia typically require weeks to months of treatment

Efficacy and safety of durvalumab in locally advanced or metastatic urothelial carcinoma: Updated results from a phase 1/2 open-label study

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Heres the whole thing in plain terms: What they did: built and validated a lab-grade method to accurately measure 5A1MQ in the blood, then dosed rats two ways intravenous (IV) and oral and tracked exactly how much showed up in circulation over time