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We also used a competitive antigen-specific, T cell receptor (TCR)-dependent proliferation assay (OT-II) and a competitive homeostatic proliferation assay to assess T cell proliferation and differentiation in vivo

Surgical lens extraction remains the standard treatment, which, despite its effectiveness, carries potential postoperative risks and economic burdens, thereby underscoring the need for alternative, non-surgical therapeutic approaches

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Unfortunately, the prognosis remains poor, with a median overall survival (mOS) of 20.9 months and a median progression-free survival (mPFS) of 6.7 months ( Here, we will discuss the previously explored repurposing efforts in the treatment of GB based on targeting two of the three most altered signal transduction pathways in GB: Receptor tyrosine kinase (RTK) and cyclin-dependent kinase (CDK)-retinoblastoma (Rb) ( Despite an increased understanding of GB tumor biology with discoveries of potential targets, the unique challenges posed by this aggressive tumor continue to thwart treatment benefits