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Balsano, C., Liver-spleen axis in nonalcoholic fatty liver disease

First introduced in 1927, insulin shock therapy was devised by Manfred Sakel, an Austrian neuropsychologist, after he observed an improvement in the psychiatric condition of one of his patients with a morphine addiction when he recovered from a hypoglycaemic coma accidentally induced by too much insulin

Given the absence of long-term human trial data, conservative use under clinical supervision is the standard position among practitioners who take the evidence seriously