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Chemotherapy is key for many patients, and antioxidants might help with side effects

As cartilage degrades, proteoglycan content decreases, leading to thinner, stiffer, and more vulnerable joint surfaces

In the context of GH and IGF-I physiology it can be concluded that 1) during childhood and adolescence the combined actions of GH and IGF-I in the presence of sufficient nutrition promote longitudinal growth and somatic maturation, 2) continued excess IGF-I activity in adulthood increases the risk for cardiovascular and neoplastic diseases and hence reduces longevity, 3) calorie restriction, which suppresses IGF-I activity and stimulates GH secretion, may promote longevity in human adults (82)

Orvosi hetilap 153 (15): 574585