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Box: Hydroxocobalamin dosing schedule for the management of pernicious anaemia If no neurological involvement: Loading dose: 1,000 micrograms three times per week for two weeks Maintenance dose: 1,000 micrograms every two to three months If neurological involvement: Loading dose: 1,000 micrograms every other day until no further improvement Maintenance dose: 1,000 micrograms every two months Injections are usually administered at a GP surgery, although some patients can be taught to self administer[22]

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Purified Water, Ethylhexyl Palmitate, Glycereth-26, Glycerin, Cetearyl Alcohol, Niacinamide, Hydrogenated Poly(C6-14 Olefin), Beeswax, Caprylic/Capric Triglyceride, Polyglyceryl-2 Stearate, Dipropylene Glycol, Isododecane, Glyceryl Stearate, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Stearyl Alcohol, Glycol Stearate SE, Sodium Polyacrylate, Hydroxyacetophenone, Stearic Acid, Dimethiconol, Dimethicone/Vinyl Dimethicone Crosspolymer, Hydrogenated Polydecene, Hydrogenated Lecithin, Tranexamic Acid (1,000ppm), Betaine, Glutathione (1,000ppm), Panthenol, Hippophae Rhamnoides Fruit Oil, Butylene Glycol, Adenosine, Sorbitan Isostearate, Caprylyl Glycol, Trideceth-6, 1,2-Hexanediol, Disodium EDTA, Sodium Hyaluronate, Ascorbic Acid

For suspected DVT particularly unilateral leg swelling with pain seek same-day assessment at an A&E or ambulatory care unit able to arrange urgent duplex ultrasound, in line with NICE NG158