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Disclosures: Vivian Rotman: Nothing to Disclose, Ana Carolina Cardoso: Nothing to Disclose, MARIA CHIARA CHINDAMO: Nothing to Disclose, Adriana Bottino: Nothing to Disclose, Joao Marcello de Araujo-Neto: Nothing to Disclose, aline ferraz pereira: Nothing to Disclose, LAIS Veiga: Nothing to Disclose, Nathalia Carraro Eduardo de Castro: Nothing to Disclose, DEBORA Canoilas: Nothing to Disclose, Andreia Evangelista: Nothing to Disclose, Renata Perez: Nothing to Disclose 2448 BURDEN OF COMORBID PSYCHIATRIC ILLNESSES AMONG HOSPITALIZED PATIENTS WITH AUTOIMMUNE LIVER DISEASE: A NATIONWIDE COHORT ANALYSIS Carla Barberan Parraga 1 Leandro Sierra 2 Diana Cheung 1 Kundan Jana 1 Marwan Alsaqa 3 Nazli Begum Ozturk 4 Butros Fakhoury 5 Syed Kodilinye 1 Ahmed Salem 1 Yasutoshi Shiratori 1 James Park 6 , 1 Maimonides Medical Center, 2 Beth Israel Deaconess Medical Center, 3 BIDMC HMS, 4 Beaumont Hospital, Royal Oak, 5 St Elizabeth's Medical Center, 6 Northwell Health Background: Autoimmune liver disease patients experience significant cognitive decline, which is linked to anxiety and depression, increasing the risk of unplanned hospitalizations, hepatic encephalopathy admissions, and mortality
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Under endotoxin shock, the activity of the key antioxidant enzyme Glutathione Peroxidase 4 (GPX4) in alveolar epithelial cells decreases significantly, leading to the lethal accumulation of lipid peroxides on membrane systems (54)
