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All previously discussed protective agents are summarized in Table 1, which serves as a comparative table to illustrate the molecular target, experimental model, and key outcomes associated with each protective agent

Health effects of grape seed and skin extracts and their influence on biochemical markers

184,185 Upregulated USP20 expression in oxaliplatin-resistant HCC cells is associated with poor prognosis, while genetic knockdown or pharmacological inhibition of USP20 can trigger ferroptosis and increase the sensitivity of HCC cells to oxaliplatin both in vitro and in vivo

Medications like antidepressants can also be helpful to deal with underlying issues like depression or anxiety