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Similarly, mouse immature DCs were genetically engineered to secrete exosomes expressing the Lamp2 protein fused with the iRGD peptide (CRGDR/KGPDC) and demonstrated highly efficient targeted drug delivery to v integrin-positive breast cancer cells, consequently inhibiting tumor growth 36

On the other hand, the physiology underlying behavior seen at the whole organ level cannot be understood without basic mechanistic knowledge at the lower levels of organization

In endothelial cell models, BPC-157 significantly enhanced ERK1/2 phosphorylation in a dose-dependent manner, leading to increased cellular proliferation, migration, and vascular tube formation mediated through downstream activation of transcription factors c-Fos, c-Jun, and EGR-1

The relationship of poor linear growth velocity with neonatal illness and two-year neurodevelopment in preterm infants