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Reconstituted epitalon requires refrigeration at 2 to 8 degrees Celsius and remains stable for approximately 4 to 6 weeks

Human data is limited primarily to topical dermatological applications

The transfer half-life between plasma and effect site was 21.1 min (95% CI 11.134.7 min) and 19.8 min (95% CI 11.934 min) with spline and compartmental approaches, respectively, and miosis occurred with EC 50 of 207 or 230 ng/ml, respectively

Understanding the principles of pharmacokinetics is important in medicine because knowing the pharmacokinetic characteristic of the drug allows prescribers to base dosing on both drug characteristics and the patient's physiological state