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Treatment with 5-amino-1mq upregulates proliferationrelated genes (Ki67, PCNA), promotes cell cycle progression, and improves cell fusion efficiency to form more multinucleated myotubes, achieving functional levels similar to those of young mice.Additionally, 5-amino-1mq inhibits muscle stem cell apoptosis, reduces oxidative stress damage, and maintains stemness

In addition to its pro-differentiating actions, nicotinamide promotes neuronal survival, especially in oxidative stress environments, through various pathways, such as maintenance of protein kinase B (akt)-dependent phosphorylation of forkhead transcription factor (FOXO3a)

Non-Invasive Monitoring Tools: The development of non-invasive technologies to monitor senescence burden and therapy efficacy will be pivotal in advancing clinical practice

Kim, S., Lim, I