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Even though some studies have shown that alveolar type II cells can supplement endogenous synthesis of GSH with the uptake of exogenous GSH (11, 12), the antioxidant effectiveness of exogenously administered GSH is hindered by its instability when crossing cell membranes and its rapid hydrolysis in the circulation (13-15)

Matrigel (356231), 8 m transwell plates were brought from Corning Incorporated

Cyclic adenosine monophosphate (cAMP) levels activate protein kinase A, resulting in phosphorylation and activation of SIRT1 (Wan et al., 2016)

486 In addition, cells undergoing senescence enhance tumor suppression by cell-extrinsic manner