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The side functions were protected by Z group (= benzyloxycarbonyl-) for lysine and O-t-Bu group (t-butylester) for aspartic and glutamic acid

The Endocrine Society's 2020 position statement on peptide therapeutics emphasizes that "the absence of Phase I dose-escalation data for novel peptides like BPC-157 means that any dose recommendation is extrapolated, not validated, and clinicians should err on the side of the lowest effective dose" 19

Early biochemical changes occur, such as an increase in homocysteine and methylmalonic acid (MMA), which indicate impaired B12 function

For more information about generic drug approval and bioequivalence, you can visit the FDA website: Dosage: Generic cyanocobalamin is available in different forms and strengths: Vials: 1000 mcg/ml in 10 ml and 30 ml vials Ampoules: 1000 mcg/ml in 1 ml ampoules Your doctor will determine the appropriate dosage based on the individual needs and medical conditions