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Owen, G

5.10 Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use Concomitant administration of topiramate and valproate has been associated with hyperammonemia with or without encephalopathy in patients who have tolerated either drug alone

Data on study quality indicators, including risk of bias (e.g., random sequence generation, allocation concealment, blinding), were also collected to facilitate further analysis