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[DOI] [PMC free article] [PubMed] [Google Scholar] [71].Wu Z, Geng Y, Lu X, et al

In this way, the sulfhydryl group of cysteine can undergo oxidation and form a dimer with another molecule of oxidized glutathione identified by the acronym GSSG binding through a sulfide bridge

This temporal regulation of autophagy genes promotes A degradation through the activation of astrocytic autophagy, whereas the pharmacological inhibition of autophagy exacerbates mitochondrial dysfunction and oxidative stress, ultimately leading to astrocyte death

This finding suggests that the topical effect of GSSG on the inflammatory response occurs via UV-induced oxidative stress