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Rethinking hypertensive kidney disease: arterionephrosclerosis as a genetic, metabolic, and inflammatory disorder

Corticosteroids such as prednisone, dexamethasone, methylprednisolone, and a closely related drug known as repository corticotropin injection (Acthar Gel) can help suppress disease activity during acute flares, or when there is severe kidney or central nervous system (brain and spine) involvement

De novo synthesis of serine from the glycolytic intermediate 3-phosphoglycerate (3-PG) occurs through a pathway consisting of three sequential steps: phosphoglycerate dehydrogenase (PHGDH) oxidizes 3-PG to 3-phosphohydroxypyruvate (pPYR) using an NAD + cofactor, phosphoserine aminotransferase (PSAT) transaminates pPYR to phosphoserine (pSER) using glutamate as the nitrogen donor, and finally phosphoserine phosphatase (PSPH) dephosphorylates pSER to produce serine [68]

Gregory Nussen: QFWFQ (The Vault) Winner of Best Solo Theatre and the Sydney Fringe Exchange at the 2025 Hollywood Fringe, with an additional three nominations including Top of Fringe, and a BroadwayWorld LA nomination for Best Solo Production