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We thank the Swiss Oncology Group as our sponsor and the European Blood and Marrow Transplantation Pediatric (EBMT) working disease group for their support and for labeling this study as an EBMT trial

These data indicate that the overall magnitude of brain injury induced by the TBI procedure, measured as BBB disruption, was comparable for each group of mice and moreover, preinjury supplementation with Immunocal had no discernible protective effect against the primary mechanical injury induced by a moderate TBI

However, of all the medications examined, metformin was most strongly statistically, significantly correlated with reduced plasma magnesium concentration

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