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A closer examination of the molecular changes elicited by HPV viral oncoproteins via their physical interaction with cellular components will certainly help to elucidate the network of effects generated by these viruses during infection and transformation

Though M1 and M2 represent the two extreme phenotype characteristics of macrophage activation stages regulated by redox metabolism, tissue-resident macrophages comprise a distinct subset and hold tissue-specific functions dependent on oxygen and nutrient supply, which can certainly influence redox status and metabolism (112)