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in the intestines, it destroys tight junctions, resulting in bacterial translocation and forming a gut-lung interactive inflammatory cycle (156)

This work was supported by Fundacin de la Asociacin Espaola contra el Cncer (AECC) grant PROYE20060CAMP to M.R.C., grant PID2022-138880OB-I00 funded by MCIN /AEI /10.13039/501100011033 / FEDER, UE to M.L.T., grant PID2020-115218RB-I00 funded by MCIN/AEI/10.13039/501100011033 to T.I., and Instituto de Salud Carlos III (CIBERNED) to T.I

We first assessed serum zonulin levels in two independent cohorts of established RA and found elevated zonulin levels compared to healthy controls (Fig