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Intraputaminal AADC gene therapy (VY-AADC01) for advanced Parkinsons disease: interim results of a phase 1b trial

Their short lifespan and segmented nucleus set them apart [54]

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal

When the central repressors of ferroptosis, such as glutathione (GSH) and lipid enzyme glutathione peroxidase 4 (GPX4) [103], which participate in peroxide reduction and reduce product toxicity, show insufficient activity, the lipid radicals formed cannot be cleared and continue to generate new oxidative products via chain reaction