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Recent evidence suggests that Bmal1 increases H2Bub1 levels by regulating the circadiancontrolled gene TTK, while H2Bub1 in turn positively modulates the expression of Bmal1 [248]

Further research is necessary to evaluate the feasibility of using this therapeutic strategy in vivo and in clinical trials

As lysosome quantity rises, so does their activity, manifesting as elevated levels of the lysosomal enzyme Senescence-Associated -Galactosidase (SA--gal) [26]