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muciniphila (pAKK), a mucosal-associated gut symbiotic bacterium, demonstrates the ability to address multiple metabolic disorders (Zhang et al., 2019)

Fe overload triggers direct mitochondrial membrane lipid peroxidation via Fenton reaction-derived hydroxyl radicals, while Cd impairs mitochondrial antioxidant defenses by suppressing glutathione peroxidase 4 (GPX4) activity

For instance, a 12-week trial showed that omega-3 fatty acids supplementation significantly improved cognitive function and increased brain-derived neurotrophic factor (BDNF) levels, while reducing inflammatory markers such as IL-6, TNF- and C-reactive protein (CRP) (244)

Although promising, further investigation into the specific roles of vitamin E subgroups will be important to clarify the efficacy of vitamin E in clinical disease