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The uptake of tumor-derived microparticles triggers transcriptional reprogramming in macrophages within the early metastatic lung [130]

[DOI] [PubMed] [Google Scholar] 380.Che L, Wang Y, Sha D, Li G, Wei Z, Liu C, et al

When these dont work properly, blood flows in the reverse direction, collect in the veins, weakens the wall of the veins and make them appear swollen or bulging