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143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH

Moreover, when considering the relationship between high HDL-C levels and increased all cause and CV mortality, relevant factors to be evaluated are sex differences together with the presence of CVD and other comorbidities

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