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Cunningham RL, Singh M, OBryant SE, Hall JR, Barber RC

(13) was negative, but the measurement of AGE was in skin, which not be reached by a significant concentration of these nutrients (vs the heart and kidneys, thru' which they would of course travel in the blood when they're taken on an empty stomach) (tho' (11) did find reductions in hexosyllysine), and their conclusion was (reasonably) that "treatment may need to continue for more than 1 year before clinical status improves." [ Edit: nixed the arginine, due to concerns raised by viveutvivas ]

00%, and the upper limits of the 90% CIs for the intraindividual variability ratios were 2.5

Methylation is such an important and complex part of our metabolism, it can be tricky because addressing it can be beneficial to one part of the body while aggravating symptoms in another area