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PMID: 102 WangJWangJYuZWenHZhaoCZhongJet al

Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions

Taken together, these studies suggest that C-terminal truncated Syn variants may act as molecular decoy sequestering heterogeneous molecules, both proteins and membrane organelles, in their vicinity through nonfunctional interaction, leading to diffuse cellular aggregates or LB nucleation, as observed in various neurodegenerative disorders 83

Opioids and depression Prescription opioids are frequently abused, with nearly 30% of chronic pain patients misusing them and about 12% developing opioid use disorder 58