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For type 2 diabetes, 452 observations from 83 cohort studies across 68 locations were analysed (Supplementary Tables 9 and 10) 69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151

Ideal candidates include individuals experiencing unexplained fatigue unresponsive to sleep and stress management, vegetarians and vegans lacking dietary B12 sources, adults over 50 with age-related absorption decline, patients with digestive disorders affecting nutrient absorption, those taking medications that deplete B12, and anyone seeking natural energy support without stimulants

Williams DS, Cash A, Hamadani L, Diemer T: Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway