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An especially sensitive event that relies on a sufficient amount of folate is the closure of the neural tube, the precursor to the brain and spinal cord

Nrf2 interacts with the NF-B signaling pathway, and its depletion enhances NF-B activity, thereby augmenting cytokine production

The reaction mixture was applied to a real-time PCR apparatus (Applied Biosystems 7500, USA)

Most of the energy deposited in cells is absorbed initially in water (because the cell is approximately 80% water), leading to the rapid (ie, within 10 14 to 10 4 s) production of reactive intermediates (oxidizing and reducing radicals), which, in turn, can interact with other molecules in the cell (indirect effect)