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(100) developed a nano-polymeric drug system (NanoDOPA) to enhance the brain delivery and therapeutic efficacy of L-dopa in a mouse model of PD

In addition, OMT can have a significant regulatory effect on apoptosis by blocking the PI3K/Akt signaling pathway and preventing DSS-induced downregulation of Bcl-2 and Bad with upregulation of caspase-3 and caspase-9 expression in colonic tissues (Li et al., 2022)