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Mechanism of arylating quinone toxicity involving Michael adduct formation and induction of endoplasmic reticulum stress

And bacterial contamination becomes a risk once preservatives in the solution begin to degrade, which happens faster at higher temperatures

Besides, berberine down-regulates the expression of acetylcholinesterase and inhibits acetylcholinesterase activity in Alzheimers disease model mice hippocampus which induced by heavy metals, in addition, berberine normalizes the production of inflammatory factors, such as tumor necrosis factor-alpha (TNF-), IL-6, IL-1 (Hussien et al., 2018)