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Comparative efficacy and tolerability of antidepressants for acute bipolar depression in adults In the above-mentioned systematic review and network meta-analysis [7], antidepressants seemed to be an efficacious drug class but were associated with a higher risk for manic switch than antipsychotics [7]

But this is the reality of drug development (talking as a former CRA) Phase 3 trials take time, and they should take time, because thats how we ensure safety and efficacy at scale

If the committee recommends inclusion, the FDA would still need to complete its review and rulemaking process before formally adding any of the substances to the 503A Bulks List

Or, to put it in terms framed so ably by Mr Banks in Mary Poppins, wellness these days has to avoid transmitting the vibe that it is still rooted in slipshod, sugary female thinking