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Studies indicate: Enhanced transcription of growth hormone messenger RNA in somatotrophs Increased pituitary growth hormone synthesis and storage capacity Preservation of somatotroph cell populations during aging Maintenance of pituitary reserve capacity with chronic administration This transcriptional effect distinguishes sermorelin from compounds that merely trigger release of existing hormone stores without supporting sustained pituitary function

Together, these studies emphasize the importance of considering underlying comorbidities when prescribing treatments, and their impact on bronchodilator efficacy in patients with COPD

All other authors declare that there is no conflict of interest