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In mice, daily oral administration of a high dose of ergothioneine (70 mg/kg/d) for 28 d showed that while ergothioneine primarily accumulated in liver and whole blood, levels also increased in multiple tissues including kidney and brain (Reference Tang, Cheah and Yew38)

We further assayed hepatic Acsm3 expression, and the results showed that it was also markedly decreased in MetS mice (Fig

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