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Clinical signs of difficult ambulation or associated cartilage lesions have not been observed in 29 to 34 week old puppies following daily treatments of 25 mg/kg for 30 consecutive days nor in 2 week old puppies with the same treatment schedule

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Pharmacoepidemiol Drug Saf 28(9):1194-203 2019 PMC6728166 Wartko PD, Weiss NS, Enquobahrie DA, Chan KCG, Stephenson-Famy A, Mueller BA, Dublin S

It has previously been shown that dieldrin resistant mosquitoes exhibit significant fitness costs including behaviour and mating competitiveness 35,36 that should lead to a decrease in the frequency of the resistant allele from the population overtime