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Yang M-Q, et al

However, AMPs therapy still has shortcomings, including cause systemic and local toxicity, decreased sensitivity to salt, serum, and pH, sensitization and allergy after repeated application, confounding biological functions (e.g., angiogenesis) and high manufacturing costs ( 3.3 Phytochemicals therapy The therapies bacteriophage and antimicrobial peptides bear high production costs and display low safety performance, easily causing local or systemic toxicity

the observable clinical effect depends on the underlying condition, dose, and frequency of administration.

Tissues used in the remaining figures are adult 68-month-old C57BL/6J male mice (Jackson Laboratory)