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250 Posttranslationally, HDAC2 deacetylates STX17, facilitating autophagosomelysosome fusion

doi: 10.1016/j.jep.2023.117603 22

Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature

According to further features in preferred embodiments of the invention described below provided is a pharmaceutical composition for therapeutically or prophylactically treating an individual known to have a central nervous system neurodegenerative disorder associated with oxidative stress, the composition comprising a compound, the compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the individual